to assume makes an ASS out of U and ME

To assume makes an ASS out of U and ME is a phrase which uses a play on words and is basically a literal term combined with a figurative term that means you should not assume things because you end up looking unintelligible. To assume makes an ASS out of U and ME actually uses all the letters in the word to create the idiom, since ASS, U and ME spell assume when the letters are put together in that order.